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KMID : 0984920090110010035
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Journal of Skin Barrier Research
2009 Volume.11 No. 1 p.35 ~ p.54
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Skin barrier, calcium and cytokines
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Kim Hyun-Jung
Jeong Se-Kyoo
Lee Seung-Hun
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Abstract
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A Ca2+ gradient is crucial to the normal development of skin, and to the process of wound healing. The epidermal permeability barrier is established late in fetal development. Coincident with permeability barrier formation, the Ca2+ gradient, low in basal and spinous layers and highest in the granule layer, develops (Elias et al., 1998). The Ca2+ gradient has been shown to regulate lamellar body secretion independent of barrier formation. CaR?/? mice have abnormalities in epidermal development, with enhanced numbers of proliferating keratinocytes and a decrease in expression of late markers of differentiation including filaggrin, and loricin (Komuves et al., 2002). Conversely, transgenic mice overexpressing CaR in basal cells of the epidermis, driven by the human keratin 14 promoter, have precocious fetal barrier formation, early hair follicle development, hypertrophic epidermis with an increase in spinous and granular layers and overexpression of terminal differentiation markers including filaggrin, involucrin and loricin ). CaR is thus a critical sensor of the epidermal Ca2+ gradient during epidermal development, stimulating migration as well as initiation of the program of keratinocyte differentiation
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KEYWORD
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Permeability barrier, Keratinocyte, Ca2+ gradient, Cytokines
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